Studies with mouse pituitary thyrotropic tumors. V. Effect of various thyroxine analogs on growth and secretion.

نویسندگان

  • R GRINBERG
  • J TIERNEY
  • S C WERNER
چکیده

A number of thyroxine derivatives have been studied for effects on growth and secretory ac tivity of mouse pituitary thyrotropic tumors. Three tumors, dependent-responsive (4183), auton omous responsive (L24), and autonomous nonresponsive (L23), were employed. No unique abil ity to suppress tumor growth was demonstrated, and most of the analogs were found to be inactive. Augmentation in growth rate of the autonomous nonresponsive tumor line in thyroidectomized mice ("reverse responsiveness") occurred with

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عنوان ژورنال:
  • Cancer research

دوره 22  شماره 

صفحات  -

تاریخ انتشار 1962